Comparative assessment of human salivary α-amylase inhibitor from Indonesian herbs

Authors

  • Khomaini Hasan Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia https://orcid.org/0000-0002-7395-4206
  • Angga Himas Setyawan Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia
  • Muhamad Abidin Universitas Padjadjaran, Jalan Singaperbangsa 2, Bandung, West Java, Indonesia
  • Nurul Aida Fathya Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia
  • Dewi Ratih Handayani Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia
  • Desy Linasari Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia
  • Saronom Silaban Universitas Negeri Medan, Medan 20221, Indonesia
  • Toto Subroto Universitas Padjadjaran, Jalan Singaperbangsa 2, Bandung, West Java, Indonesia
  • Muhammad Yusuf Universitas Padjadjaran, Jalan Singaperbangsa 2, Bandung, West Java, Indonesia

DOI:

https://doi.org/10.24114/jpkim.v15i3.51153

Abstract

Diabetes mellitus (DM) is a multifactorial disease defined by persistent hyperglycemia and impaired carbohydrate, lipid, and protein metabolism due to a lack of insulin secretion. The objective of this study was to assess the Indonesian herbs which have the ability to act as human salivary Î±-amylase inhibitors, thus, that they can be implemented for medical purposes. In this study, fifteen Indonesian herbs were assessed for their capability as Î±-amylase inhibitor. The water-reflux method was used to extract all potential water-soluble active components. The Fuwa technique was used to test Î±-amylase activity. There were significant variations in the effects of herbs on salivary Î±-amylase activity, according to the statistical using one-way ANOVA and Post Hoc Tukey between the with and without inhibitors. According to the findings, Turmeric (Curcuma longa L.) and pandan leaf (Pandanus amaryllifolius Roxb) had the highest inhibitory power (80%).Keywords: Diabetes mellitus; Flavonoids; Herbs; Î±-amylase inhibitors

Author Biographies

Khomaini Hasan, Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia

Faculty of Medicine

Angga Himas Setyawan, Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia

Faculty of Medicine

Muhamad Abidin, Universitas Padjadjaran, Jalan Singaperbangsa 2, Bandung, West Java, Indonesia

Pusat Riset Bioteknologi Molekular dan Bioinformatika

Nurul Aida Fathya, Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia

Faculty of Medicine

Dewi Ratih Handayani, Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia

Faculty of Medicine

Desy Linasari, Universitas Jenderal Achmad Yani, Jalan Terusan Jenderal Sudirman, PO Box 148, Cimahi, West Java, Indonesia

Faculty of Medicine

Saronom Silaban, Universitas Negeri Medan, Medan 20221, Indonesia

Department of Chemistry, Faculty of Mathematics and Natural Science

Toto Subroto, Universitas Padjadjaran, Jalan Singaperbangsa 2, Bandung, West Java, Indonesia

Pusat Riset Bioteknologi Molekular dan Bioinformatika

Muhammad Yusuf, Universitas Padjadjaran, Jalan Singaperbangsa 2, Bandung, West Java, Indonesia

Pusat Riset Bioteknologi Molekular dan Bioinformatika

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Published

2023-12-02

Issue

Vol. 15 No. 3 (2023): December

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Articles

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Copyright (c) 2023 Khomaini Hasan, Angga Himas Setyawan, Muhamad Abidin, Nurul Aida Fathya, Dewi Ratih Handayani, Desy Linasari, Saronom Silaban, Toto Subroto, Muhammad Yusuf

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