Synthesis and characterization of capsule shells non gelatin grass jelly leaves-seaweed as drug delivery system material
DOI:
https://doi.org/10.24114/jpkim.v13i1.24138Abstract
Drug delivery system is a system that describes the journey of a drug to its target location. The main component of the drug delivery system is gelatin. The leaves of grass jelly-seaweed are needed as a raw material for gelatin. The main component of gelling agents in grass jelly leaves and seaweed is a low-methoxy pectin polysaccharide. Pectin from previous study is used as a synthesis material for hard capsule shells with the addition of other ingredients, which are Na-CMC, sorbitol, and water. The characterization results of capsule shells with variations in the composition of grass jelly-seaweed leaves 0: 4, 1: 3, 2: 2, 3: 1, and 4: 0 (A, B, C, D and E) have a disolving time of 12 minutes 45 seconds; 15 minutes 53 seconds; 23 minutes 10 seconds; 15 minutes 35 seconds and 18 minutes 12 seconds. The swelling degree test each of 200%; 266,7%; 303.3%; 586.7% and 643.3%. Furthermore, the shells of grass jelly-seaweed leaf capsules were tested for their material performance in the cefadroxyl disolving test with variations in sampling time of 10, 20, and 30 minutes.Keywords: Cefadroxyl, Drug delivery system, Green grass jelly leaves, Non-gelatin capsules, SeaweedReferences
Amin, F., Mahardika, M., & Morisca, N. (2019). Synthesis and characterization of gold nanoparticles using fruit extract of Crescentia cujete L. Jurnal Pendidikan Kimia, 11(3), 95“99. DOI: 10.24114/jpkim.v11i3.15737
Fauzi, M.A. 2016. Kopolimer alginat-karagenan dengan adisi plasticizer sorbitol sebagai material drug delivery carrier. Thesis. Fakultas Sains dan Teknologi.Universitas Airlangga. Surabaya
Gohel, M. C., Mehta, P. R., Dave, R. K., & Bariya, N. H. (2004). A More Relevant Dissolution Method for Evaluation of Floating Drug Delivery System. Dissolution Technologies, 11(4), 22“25. DOI: 10.14227/dt110404p22
Harefa, N., & Silaban, S. (2020). Identification of metal content in food using gravimetric and iodometric methods: The case on children's food. Jurnal Pendidikan Kimia, 12(2), 52-61. DOI: 10.24114/jpkim.v12i2.19395
Harianto, H., Tazwir, T., & Peranginangin, R. (2008). Studi teknik pengeringan gelatin ikan dengan alat pengering kabinet. Jurnal Pascapanen Dan Bioteknologi Kelautan dan Perikanan, 3(1), 89. DOI: 10.15578/jpbkp.v3i1.13
Hidayana, D. A., Herawati, E. D., & Aprilia, W. H. (2018). Karakterisasi dan pembuatan cangkang kapsul dari tepung pektin lidah buaya [Aloe vera (L.) Burm. f] sebagai alternatif bahan pembuatan cangkang kapsul keras. Institut Pertanian Bogor, Bogor.
Karimah, M. (2016). Pembuatan dan karakterisasi kapsul pati-alginat dari ekstraksi rumput laut coklat (Sargassum sp.) sebagai material drug delivery system. Skripsi. Universitas Airlangga.
Kementrian Kesehatan Republik Indonesia. (2014). Farmakope Indonesia Edisi V. Jakarta.
Lestari, M., Nasution, M. P., & Suryani, S. (2015). Potensi ekstrak etanol daun lidah buaya (Aloe vera L.) sebagai antifertilitas melalui tampilan imunohistokimia caspase 3 aktif pada testis serta penilaian kuantitas dan kualitas spermatozoa mencit (Mus musculus L.). Jurnal Pendidikan Kimia, 7(2), 21-30.
Raja, P. M, & Nurfajriani, N. (2017). Pembuatan adsorben dari kitosan cangkang belangkas (Tachypleus gigas) dan gelatin untuk menurunkan kadar logam timbal (Pb). Jurnal Pendidikan Kimia, 9(1), 282“285. DOI: 10.24114/jpkim.v9i1.6203
Shargel, L., Wu-Pong, S., & Yu, A. B. (2007). Applied biopharmaceutics & pharmacokinetics. Mcgraw-hill.
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