Triterpenoid compound from metanol extract of mangrove leaves (Sonneratia alba) and anti-cholesterol activity test

Authors

  • Weny J.A Musa Gorontalo State University, Indonesia
  • Nurhayati Bialangi Gorontalo State University, Indonesia
  • Boima Situmeang Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Indonesia
  • Saronom Silaban Universitas Negeri Medan, Medan 20221, Indonesia

DOI:

https://doi.org/10.24114/jpkim.v11i1.13124

Abstract

Mangrove plant (Sonneratia alba) is easily found in West and North Indonesia. Mangrove plant has the potential of being a herb medicine. Mangrove plant variously used in ethnomedicine to treat various deseases like wounds, diarrhea, and fever. In previously sutudy, leaf extract of mangrove plants reported have anti-cholesterol activity. This plant is widely used to treat various deseases like wounds, diarrhea, and fever. The purpose of this study was to isolate triterpenoid compound from the ethyl acetate fraction of mangrove leaves and anticholesterol activity test. Extraction was done by maceration method using methanol 96% as solvent. Isolation was carried out by column chromatography using a combination of n-hexane, ethyl acetate, and methanol solvents. The elucidation of the structure was determined by analysis of IR, 1H-NMR, 13C-NMR, 2D-NMR, and MS spectroscopies as well as by comparisons with the literature. Anticholesterol activity test was carried out in vitro. The results showed that triterpenoid compounds (lupeol) were able to reduce cholesterol from concentrations of 5, 10, 20, 40, 60, and 80 ppm are 13.7; 29.4; 49.0; 60,1; 70.2; and 77.0% respectively. Therefore, isolates compound (lupeol) have anti-cholesterol activity.Keywords:Anti-cholesterol; mangrove; triterpenes

Author Biographies

Weny J.A Musa, Gorontalo State University, Indonesia

Department of Chemistry, Faculty of Mathematic and Natural Science

Nurhayati Bialangi, Gorontalo State University, Indonesia

Department of Chemistry, Faculty of Mathematic and Natural Science

Boima Situmeang, Sekolah Tinggi Analis Kimia Cilegon, Cilegon, Indonesia

Department of Chemistry

Saronom Silaban, Universitas Negeri Medan, Medan 20221, Indonesia

Department of Chemistry, Faculty of Mathematic and Natural Science

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Published

2019-04-30

Issue

Vol. 11 No. 1 (2019): April

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Articles

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Copyright (c) 2019 Weny J.A Musa, Nurhayati Bialangi, Boima Situmeang, Saronom Silaban

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