FORMULATION AND TEST THE EFFECTIVENESS OF ANTIHYPERLIPIDEMIC COMBINATION OF ETHANOL EXTRACT OF BITTER MELON (Momordica charantia L.) AND RED GINGER (Zingiber officinale rosc var.rubrum) AGAINST WHITE MALE RATS (Rattus norvegicus)

Abstract

Cholesterol, is one of the energy sources that provides the highest calories. In addition, cholesterol excess can cause disease.One of a plant that can reduce cholesterol levels is the combination of bitter melon and red ginger which contains flavonoids to lower cholesterol levels. This study aimed was to determine the effectiveness of the combination of red ginger rhizome extract with bitter melon in lowering cholesterol levels, and to determine the most effective dose of combination of red ginger rhizome extract with bitter melon in lowering cholesterol levels. Extraction was carried out by percolation using 96% ethanol solvent, then made into capsules, cholesterol testing was carried out using an experimental method using 35 male white rats induced with duck egg yolk and divided into 7 groups.Each group of 5 animals were given  1% CMC Na, simvastatin, ethanol extract of bitter melon fruit 100mg/Kgbb, ethanol extract of red ginger rhizome 100mg/Kgbb, ethanol extract of fruit bitter melon and red ginger each 50 mg/kg, 100 mg/kg, 150 mg/kg.The results of cholesterol testing in each the treatment group, the best reduction in cholesterol levels was combination doses of 150 mg/kgBW of bitter melon and 150 mg/kgBW of red ginger. Based the results of this study. The best reduction in cholesterol levels was the combination group with a dose of 150 mg/kgBW of bitter melon and 150 mg/kgBW of red ginger which was comparable to the simvastatin in reducing cholesterol levels.Kolesterolmerupakan salah satu sumber energi yang memberikan kalori paling tinggi. Jika dalam jumlah berlebih dapat menyebabkan penyakit. Tanaman yang dapat menurunkan kadar kolesterol adalah buah pare dan jahe merah yang memiliki kandungan flavonoid untuk menurunkan kadar kolesterol.Tujuan penelitian ini untuk mengetahui efektivitas serta dosis yang paling efektif kombinasi ekstrak rimpang jahe merah dengan buah pare dalam menurunkan  kadar kolesterol. Ekstraksi dilakukan secara perkolasi menggunakan pelarut etanol 96%, lalu dibuat dalam sediaan kapsul, uji kolesterol dilakukan menggunakan metode eksperimental menggunakan 35 ekor tikus putih jantan yang diinduksi dengan kuning telur bebek dan dibagi menjadi 7 kelompok. Tiap kelompok sebanyak 5 ekor diberikan CMC Na 1%, simvastatin, ekstrak etanol buah pare 100mg/Kgbb, ekstrak etanol rimpang jahe merah 100mg/Kgbb, ekstrak etanol buah pare dan jahe merah masing-masing 50mg/Kgbb, 100 mg/Kgbb, 150 mg/Kgbb. Dari hasil penelitian ini hasil evaluasi sediaan kapsul memenuhi syarat. Hasil pengujian kolesterol dari kelompok perlakuan, penurunan kadar kolesterol yang paling baik dosis 150 mg/kgBB buah pare dan 150 mg/kgBB jahe merah. Penurunan kadar kolestrol yang paling baik adalah kelompok kombinasi masing-masing dosis 150 mg/kgbb yang sebanding dengan simvastatin.